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Anti-obesity drugs can cause weight loss by decreasing hunger and food intake, stimulating energy expenditure, or by inhibiting the intestinal absorption of dietary fats Some centrallyacting appetite-suppressants also increase energy expenditure Many anti-obesity drugs have been withdrawn or clinical development halted because of poor efficacy and/or severe side effects, including amphetamines (high risk of dependence), fenfluramine (risk of pulmonary hypertension and valvular heart disease) and 3 adrenergic agonists (poor efficacy and sympathetic side effects) Thyroxine should not be used to treat obesity in euthyroid subjects because of adverse effects including cardiac arrhythmias Novel approaches under active investigation include inhibitors of the neuropeptide Y (NPY) Y5 receptor, which mediates NPYs powerful hyperphagic action; agonists at the melanocortin MC4 receptor, which decreases feeding; and receptor antagonists of ghrelin, an appetite-stimulating gut peptide As yet, these have not yielded effective and safe drugs suitable for use in humans.

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Jan 19, 2016 · Convert Tiff file into PDF file using iTextSharp DLL. iTextSharp.text.pdf.PdfWriter writer = iTextSharp.text.pdf.PdfWriter.GetInstance(document, new System.IO.FileStream(destPdf, System.IO.FileMode.Create)); System.Drawing.Bitmap bmp = new System.Drawing.Bitmap(sourceTif); iTextSharp.text.pdf.PdfContentByte cb = writer ...

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From a form creation point of view, no difference exists between a plug-in (module) and CGI, so I use the term CGI in the rest of this appendix. (A CGI is actually a script, or program, but at times I take the liberty of simply using CGI instead of CGI script or CGI program. All three terms are interchangeable.)

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Anti-obesity drugs are not a cure, but aim to supplement lifestyle education and change Weight loss of 5% of the pre-treatment level is unlikely to bring clinical benefits, whereas loss of 10% can decrease the risk of obesity-related comorbidities, notably type 2 diabetes and cardiovascular disease Treatment with an anti-obesity drug can be considered in patients with BMI 30 kg/m2, or BMI 27 kg/m2 together with one or more obesity-related comorbidities (eg type 2 diabetes, hypertension, dyslipidaemia or coronary-heart disease) Lifestyle modification (energy intake restriction and increased physical activity) should have been tried for three months and shown to achieve inadequate weight loss Compliance with drug therapy and continuing lifestyle modification are essential Orlistat is a semi-synthetic inhibitor of gut lipases, which decreases the absorption of dietary fat by up to 30% Dosage is 120 mg thrice daily.

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Figure 3.43. The Michelson interferometer as used in FTIR spectroscopy. The beam splitter divides an incident beam into a transmitted and re ected beam, respectively. These are re ected by a stationary mirror and a moving mirror, respectively. The re ected beams are recombined at the beam splitter and the resultant beam passes through the sample. The re ected and transmitted beams can interfere with each other (Figure 3.44) depending on the relative positions of the stationary and moving mirrors. The resultant beams detected are analysed by the Fourier Transform (Appendix 2) to generate an FTIR spectrum which is characteristic of the sample.

Side effects are the consequences of fat malabsorption, notably steatorrhoea and (potentially) deficiencies of fat-soluble vitamins Sibutramine acts centrally to inhibit the reuptake of both serotonin and noradrenaline, thus enhancing the action of both these appetite-suppressing monoamines Dosage is 10 or 15 mg once daily Problems include sympathomimetic effects such as tachycardia and dry mouth and occasionally hypertension Rimonabant is a centrally-acting antagonist at the cannabinoid CB1 receptor, which mediates the appetite-stimulating action of endocannabinoids released in the brain Dosage is 20 mg once daily Side effects include severe psychiatric problems (depression and anxiety), nausea and dizziness Licensing approval for rimonabant was withdrawn in Europe in late 2008 The three drugs in current use orlistat, sibutramine and rimonabant all achieve 10% weight loss after one year s treatment in up to one-third of cases.

=AVERAGE(C5:C7)

(10)

Weight tends to be regained during prolonged treatment, and generally returns to baseline values if the drug is withdrawn Reductions in waist circumference, indicating a decrease in visceral fat mass, are generally seen Modest improvements in obesity-related metabolic and cardiovascular risk factors hyperglycaemia, dyslipidaemia and hypertension often occur Many drugs cause weight gain, notably corticosteroids, progesterone contraceptives, certain anti-convulsant and anti-psychotic agents, -blockers, and sulphonylureas and insulin These should be prescribed with particular care, or alternatives used, in obese subjects..

10 60 10 60 10 60

6

Ethylene propylene diene rubber copolymer (EDPH) 5.32 2.57 0.03 1.42 0.66 0.47 1.12 0.83 0.80

Figure 10-1

(1.26)

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