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conditions They examined the reproduction of printed images viewed under CIE illuminant D50 and A simulators on a CRT display with a CIE illuminant D65 white point Fifteen observers took part in this experiment using ve different viewing techniques It was concluded that a successive binocular viewing technique with a 60 second adaptation period provided the most reliable results Interestingly, a simultaneous binocular viewing technique, common in many practical situations, produced completely unreliable results The experiment utilized ve different pictorial images with a variety of content The result showed signi cant differences in the performance of each model tested The order of performance from best to worst was RLAB, CIELAB, von Kries, Hunt, and Nayatani et al Fairchild et al (1996) performed a similar experiment on the reproduction of CRT displayed images as projected 35 mm slides.

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The Edwards historical study that started the investigation on the mechanism of the hydrolysis of aspirin required hundreds of kinetic experiments [12, 13] Several examples are reported by Carstensen [1] in his review on the subject where, beside the large space dedicated to the determination of the pH rate pro le, the effect of temperature, ionic strength, buffer concentration, and dielectic constant on the stability of drugs was treated Physicochemical pro ling concerns the determination of some basic molecular properties of pharmaceutical interest that can support the successive clinical studies and can help a rapid identi cation and elimination of compounds with unsuitable physicochemical and pharmacokinetic properties New accelerated methods for physicochemical pro ling have assumed particular importance in recent years because of the great amount of new chemical entities coming from modern synthetic strategies.

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How to extract images from PDF files using c# and itextsharp โ€“ Tipso ...
18 Apr 2018 ... Works with the most /// common image types embedded in PDF files, as far as I ... How to extract images from PDF files using c# and itextsharp.

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The CRT display was set up with both illuminant D65 and D93 white points at 60 cd/m2 and viewed in dim surround The projected image had a 3900 K white point at 109 cd/m2 with a dark surround Fifteen observers completed the experiment with three different pictorial images The RLAB model performed best, followed by CIELAB and von Kries with similar performance and then the Hunt model The Nayatani et al model was not included in the nal visual experiments since it produced clearly inferior images due to its prediction of the Helson Judd effect and the limited number of images that could be included in the experiment Braun and Fairchild (1997) extended the experiments of Braun et al (1996) to a wide variety of viewing conditions Ten different sets of viewing conditions were investigated using between 14 and 24 observers.

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The viewing conditions varied in white point, luminance level, background, and surround Overall, the RLAB model performed best For changes in white point, CIELAB and a von Kries transformation also performed well The Hunt and Nayatani et al models did not perform as well as those three Similar results were obtained for changes in luminance level For changes in background, the Hunt model performed poorly, apparently because it over-predicted the effect for complex images The models that did not account for changes in background performed better This result was as expected since the background of an image does not coincide with what is normally considered the background of a stimulus (ie, an image element) For changes in surround, RLAB performed worst with the Hunt model performing poorly as well.

Thousands of compounds have to be pro led each year and traditional technologies cause a bottleneck in drug development Methods have been developed for high-throughput physicochemical pro ling for solubility, permeability, pKa, lipophilicity, stability, and integrity, and a great interest from pharmaceutical industries and instrument maker groups is reserved for this subject [5, 6] Among physicochemical properties, the stability of drug candidates is receiving increasing attention Unfortunately, its evaluation very often requires a lot of experimental time and pro ling of many molecules would be nearly impossible without new, computer-aided methods Any effort useful to facilitate this rst part of pharmaceutical investigation is appreciated because it can be converted to a considerable lowering of the research cost Here a panoramic picture of the effort directed to accelerating the characterization of the reactivity in solution of molecular candidates is shown In particular,.

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